Sedimentology and stratigraphy of the Kellaways Sand Member (Lower Callovian), Burythorpe, North Yorkshire, UK

In the Burythorpe area of the Howardian Hills, located on the northern margin of the Market Weighton High, the Callovian succession is represented only by Lower Callovian sediments. These belong to the Kellaways Sand Member (Kellaways Formation), up to 12 m thick, but thinning southwards to 5 m. This contrasts with the more complete Callovian succession (Osgodby Formation) on the Yorkshire coast (Cleveland Basin) which is up to 32.5 m thick. At Burythorpe Quarry the Kellaways Sand Member has yielded palynomorphs and ammonites confirming an Early Callovian (Koenigi Zone) age with depositional hiatuses above and below. The sequence consists of a yellow-white, poorly cemented, fine-to medium grained, unimodal uncemented sand (moulding sand) with sparse grey clay beds and laminae, in marked contrast to the broadly coeval Red Cliff Rock Member (Osgodby Formation) of the Cleveland Basin. The depositional environment is interpreted as a tidally influenced shallow sea on the margin of the Market Weighton High, in a shallow sub-tidal regime, similar to the sub-tidal sand-mud lithofacies in the Heligoland region of the present-day North Sea. Winnowing of the sand in highly mobile substrate resulted in a unimodal grain size, lack of impurities, and sparse shelly- and ichnofaunas. However, during quieter water phases, grey clay laminae were deposited at the base of channels, allowing colonization of the substrate by burrowing ichnofauna and deposition of palynomorphs. Sparse, calcite-cemented tabular beds with a benthic shelly fauna, ammonites, Planolites burrows and mudstone rip-up clasts are interpreted as the deposits of periodic storm events. The marked local variation in thickness of the Kellaways Sand Member in the Howardian Hills is probably due to synsedimentary east–west-trending faulting related to the Flamborough Fault Zone

Filling the Gap: New Precise Early Cretaceous Radioisotopic Ages from the Andes

Two tuffs in the Lower Cretaceous Agrio Formation, Neuquén Basin, provided U–Pb zircon radioisotopic ages of 129.09 ± 0.16 Ma and 127.42 ± 0.15 Ma. Both horizons are well constrained biostratigraphically by ammonites and nannofossils and can be correlated with the ‘standard’ sequence of the Mediterranean Province. The lower horizon is very close to the base of the Upper Hauterivian and the upper horizon to the Hauterivian/Barremian boundary, indicating that the former lies at c. 129.5 Ma and the latter at c. 127 Ma. These new radioisotopic ages fill a gap of over 8 million years in the numerical calibration of the current global Early Cretaceous geological time scale

The Hubble Space Telescope Extragalactic Distance Scale Key Project. X. The Cepheid Distance to NGC 7331

The distance to NGC 7331 has been derived from Cepheid variables observed with HST/WFPC2, as part of the Extragalactic Distance Scale Key Project. Multi-epoch exposures in F555W (V) and F814W (I), with photometry derived independently from DoPHOT and DAOPHOT/ALLFRAME programs, were used to detect a total of 13 reliable Cepheids, with periods between 11 and 42 days. The relative distance moduli between NGC 7331 and the LMC, imply an extinction to NGC 7331 of A_V = 0.47+-0.15 mag, and an extinction-corrected distance modulus to NGC 7331 of 30.89+-0.14(random) mag, equivalent to a distance of 15.1 Mpc. There are additional systematic uncertainties in the distance modulus of +-0.12 mag due to the calibration of the Cepheid Period-Luminosity relation, and a systematic offset of +0.05+-0.04 mag if we applied the metallicity correction inferred from the M101 results of Kennicutt et al 1998.Comment: To be published in The Astrophysical Journal, 1998 July 1, v501 note: Figs 1 and 2 (JPEG files) and Fig 7 (multipage .eps file) need to be viewed/printed separatel

Association of functional polymorphisms from brain-derived neurotrophic factor and serotonin-related genes with depressive symptoms after a medical stressor in older adults

Depressive symptoms are common in older adults after a disabling medical event and interfere with rehabilitation and recovery from the disability. This prospective study examined the role of genetic polymorphisms implicated in synaptic integrity and stress-associated depression as predictors of depressive symptoms after hip fracture. We recruited healthy comparisons from the community and participants with hip fracture after surgical fixation from Saint Louis, Missouri hospitals. We examined the valine (Val) to methionine (Met) polymorphism in brain-derived neurotrophic factor (BDNF), serotonin 1A receptor (5HT1a-rs6295) polymorphism, and the serotonin transporter-linked polymorphic region (5HTTLPR) interaction with the rs25531 A to G single nucleotide polymorphism (5HTTLPR-rs25531) as predictors of depressive symptoms. We also examined whether depressive symptoms mediate the influence of BDNF genotype on functional recovery. Among 429 participants with hip fracture, BDNF Met/Met carriers developed significantly more depressive symptoms than Val/Val carriers during a four-week period after the fracture (p=.012). BDNF genotype also predicted functional recovery over the ensuing year, mediated by its effects on depressive symptoms (CI: 0.07-3.37). Unlike prior studies of stressful life events, the S' 5HTTLPR-rs25531 variant did not predict higher levels of depressive symptoms; instead, we report an exploratory finding of an epistatic effect between BDNF and 5HTTLPR-rs25531 whereby the compounded effects of two LA alleles and BDNF Met/Met genotype elevate risk of depressive symptoms after hip fracture (p=.006). No differences between 5HT1a genotypes were found. Our findings suggest plasticity-related genetic factors contribute to the neural mechanisms of mental and functional well-being after a disabling medical stressor

The Extragalactic Distance Scale Key Project. XVI. Cepheid Variables in an Inner Field of M101

We report on the identification of 255 candidate variable stars in a field located some 1.7 from the center of the late-type spiral galaxy M101 = NGC 5457, based on observations made with the Wide Field and Planetary Camera 2 on board the Hubble Space Telescope

The HST Key Project on the Extragalactic Distance Scale XIV. The Cepheids in NGC 1365

We report the detection of Cepheid variable stars in the barred spiral galaxy NGC 1365, located in the Fornax cluster, using the Hubble Space Telescope Wide Field and Planetary Camera 2. Twelve V (F555W) and four I (F814W) epochs of observation were obtained. The two photometry packages, ALLFRAME and DoPHOT, were separately used to obtain profile-fitting photometry of all the stars in the HST field. The search for Cepheid variable stars resulted in a sample of 52 variables, with periods between 14 and 60 days, in common with both datasets. ALLFRAME photometry and light curves of the Cepheids are presented. A subset of 34 Cepheids were selected on the basis of period, light curve shape, similar ALLFRAME and DoPHOT periods, color, and relative crowding, to fit the Cepheid period-luminosity relations in V and I for both ALLFRAME and DoPHOT. The measured distance modulus to NGC 1365 from the ALLFRAME photometry is 31.31 +/- 0.20 (random) +/- 0.18 (systematic) mag, corresponding to a distance of 18.3 +/- 1.7 (random) +/- 1.6 (systematic) Mpc. The reddening is measured to be E(V-I) = 0.16 +/- 0.08 mag. These values are in excellent agreement with those obtained using the DoPHOT photometry, namely a distance modulus of 31.26 +/- 0.10 mag, and a reddening of 0.15 +/- 0.10 mag (internal errors only).Comment: 48 pages, 8 tables, 8 figures, to appear in Ap

Whole-genome sequencing of acral melanoma reveals genomic complexity and diversity

To increase understanding of the genomic landscape of acral melanoma, a rare form of melanoma occurring on palms, soles or nail beds, whole genome sequencing of 87 tumors with matching transcriptome sequencing for 63 tumors was performed. Here we report that mutational signature analysis reveals a subset of tumors, mostly subungual, with an ultraviolet radiation signature. Significantly mutated genes are BRAF, NRAS, NF1, NOTCH2, PTEN and TYRP1. Mutations and amplification of KIT are also common. Structural rearrangement and copy number signatures show that whole genome duplication, aneuploidy and complex rearrangements are common. Complex rearrangements occur recurrently and are associated with amplification of TERT, CDK4, MDM2, CCND1, PAK1 and GAB2, indicating potential therapeutic options.This work was supported by a National Health and Medical Research Council of Australia (NHMRC) Program Grant (1093017, G.J.M., R.A.S., N.H., G.V.L., J.F.T.), an NHMRC project grant (APP1123217) and NHMRC Fellowship grants (R.A.S., N.K.H. - APP1139071, G.VL.). G.V.L is supported by an NHMRC Practitioner Fellowship and the University of Sydney Medical Foundation. R.A.S is supported by an NHMRC Practitioner Fellowship. J.S.W. is supported by a NHMRC early career fellowship (1111678). N.W. is supported by an NHMRC Senior Research Fellowship (1139071). N.K.H. is supported by an NHMRC Senior Principal Research Fellowship (1117663). P.M.F. was supported by the Deborah and John McMurtrie MIA Pathology Fellowship. T.J.D. was supported by the Jani Haenke Melanoma Pathology Fellowship. Support from Melanoma Institute Australia, the Royal Prince Alfred Hospital and New South Wales Health Pathology is also gratefully acknowledged

The disruption of proteostasis in neurodegenerative diseases

Cells count on surveillance systems to monitor and protect the cellular proteome which, besides being highly heterogeneous, is constantly being challenged by intrinsic and environmental factors. In this context, the proteostasis network (PN) is essential to achieve a stable and functional proteome. Disruption of the PN is associated with aging and can lead to and/or potentiate the occurrence of many neurodegenerative diseases (ND). This not only emphasizes the importance of the PN in health span and aging but also how its modulation can be a potential target for intervention and treatment of human diseases.info:eu-repo/semantics/publishedVersio